Article
In vitro activity of OPC-17116 compared to other broad-spectrum fluoroquinolones.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology - 1 Apr 1992
Sader H S, Erwin M E, Jones R N
Abstract excerpt
The in vitro activity of OPC-17116 was compared to that of five similar fluoroquinolones (ciprofloxacin, enoxacin, norfloxacin, ofloxacin and temafloxacin). A total of 700 isolates from recent cases of clinical bacteremia were tested. Fifty additional stock strains with well-characterized resistance mechanisms were also processed. The minimal concentrations inhibiting 90% of strains (MIC90) of Enterobacteriaceae...
Topics
- Anti-Infective Agents
- Drug Evaluation, Preclinical
- Drug Resistance, Microbial
- Fluoroquinolones
- Gram-Negative Bacteria
- Gram-Positive Bacteria
- Microbial Sensitivity Tests
- Mutation
- Piperazines
- Quinolones