Article
In-vitro activity of biapenem, compared with imipenem and meropenem, against Pseudomonas aeruginosa strains and mutants with known resistance mechanisms.
The Journal of antimicrobial chemotherapy - 1 May 1994
Chen H Y, Livermore D M
Abstract excerpt
The activity of biapenem (L-627, LJC-10627), a new carbapenem, was investigated against Pseudomonas aeruginosa strains, mutants and isolates with known resistance mechanisms to other beta-lactams. The behaviour of biapenem closely resembled that of imipenem, although it showed minor differences c...
Topics
- Carbenicillin
- Enzyme Induction
- Hydrolysis
- Imipenem
- Meropenem
- Microbial Sensitivity Tests
- Mutation
- Penicillin Resistance
- Porins
- Pseudomonas aeruginosa
- Thienamycins
- beta-Lactamase Inhibitors
- beta-Lactamases