Article
Isolation and in-vitro and in-vivo characterisation of a mutant of Pseudomonas aeruginosa PAO1 that exhibited a reduced postantibiotic effect in response to imipenem.
The Journal of antimicrobial chemotherapy - 1 Oct 1994
Majcherczyk P A, Kunz S, Hattenberger M, Vaxelaire J, Zak O, O'Reilly T
Abstract excerpt
The postantibiotic effect (PAE) is the persistent inhibition of bacterial growth after a brief exposure to an antibiotic. Most beta-lactams do not induce a PAE for Gram-negative bacteria, but PAEs have been reported for carbapenems and penems. This study investigated the effect of sequential doses of imipenem on the PAE for Pseudomonas aeruginosa and Escherichia coli cultures in a chemostat. The PAE for the...
Topics
- Acetylglucosamine
- Animals
- Bacterial Outer Membrane Proteins
- Electric Conductivity
- Escherichia coli
- Female
- Imipenem
- Leukopenia
- Mice
- Mice, Inbred Strains
- Microbial Sensitivity Tests