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Article

Mechanism of enhanced antipseudomonal activity of BO-2727, a new injectable 1-beta-methyl carbapenem.

Antimicrobial agents and chemotherapy - 1 Mar 1995

Hazumi N, Fuse A, Matsuda K, Hashizume T, Sanada M

Abstract excerpt

The mechanism of the enhanced activity of BO-2727 against imipenem-resistant Pseudomonas aeruginosa was studied by using a set of four isogenic strains derived from beta-lactamase-deficient P. aeruginosa PAO4089 (blaJ blaP). Complementation of the blaJ and blaP mutations conferred greater resistance to biapenem, panipenem, and imipenem than to BO-2727 and meropenem, most notably in the outer membrane protein...

Topics

Anti-Bacterial Agents
Carbapenems
Drug Resistance, Microbial
Electrophoresis, Polyacrylamide Gel
Mutation
Pseudomonas aeruginosa
beta-Lactamases

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7793876
DOI: 10.1128/AAC.39.3.702
PMCID: PMC162608

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7793876-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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