Article
Correlative immunohistochemistry and molecular genetic study of the inactivation of the p16INK4A genes in astrocytomas.
Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Apr 1997
Rao L S, Miller D C, Newcomb E W
Abstract excerpt
Loss of p16 expression can occur via homozygous deletion, point mutation, or hypermethylation of exon 1. Astrocytomas representing all World Health Organization (WHO) grades of malignancy were analyzed in a correlative study using multiplex polymerase chain reaction (PCR) analysis to detect delet...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Astrocytoma
- Brain Neoplasms
- Carrier Proteins
- Child
- Child, Preschool
- Cyclin-Dependent Kinase Inhibitor p16
- DNA Mutational Analysis
- Female
- Gene Deletion
- Gene Expression Regulation, Neoplastic
- Genes, Tumor Suppressor
- Humans
- Immunohistochemistry
- Male