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Article

CDKN2A/p16 inactivation in the prognosis of oligodendrogliomas

1 Jan 2000

Abstract excerpt

The cell-cycle regulator p16 inhibits the complex cdk4-cyclin D1 and controls G1-S transition. In human tumors, p16 inactivation is often accomplished by homozygous deletion (HD) of its encoding gene, CDKN2A. Methylation of the 5' CpG island promoter has been proposed as an alternative mechanism of inactivation. Expression of p16, CDKN2A HD and 5' CDKN2A CpG island methylation was studied in 25 oligodendrogliomas...

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PMID: 11058870
DOI: 10.1002/1097-0215(20001115)88:4<554::aid-ijc6>3.0.co;2-q

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