Herpes simplex virus resistance to antiviral drugs.

doi:10.1016/s1386-6532(02)00263-9

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Article

Herpes simplex virus resistance to antiviral drugs.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Jan 2003

Morfin Florence, Thouvenot Danielle

Abstract excerpt

Herpes simplex virus (HSV) infections are efficiently treated with antiviral drugs such as acyclovir (ACV). However, resistance has been reported, mainly among immunocompromised patients (prevalence around 5%) and particularly allogeneic bone marrow transplant patients (prevalence reaching 30%). Resistance to ACV is associated with mutations on one of the two viral enzymes involved in the ACV mechanism of action:...

Topics

Acyclovir
Antiviral Agents
Cidofovir
Cytosine
DNA-Directed DNA Polymerase
Drug Resistance, Multiple, Viral
Drug Resistance, Viral
Enzyme Inhibitors
Exodeoxyribonucleases
Foscarnet
Herpes Simplex

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Immunocompromised Host

Mutation

Nucleic Acid Synthesis Inhibitors

Organophosphonates

Organophosphorus Compounds

Simplexvirus

Source

Open in PubMed

Identifiers

PMID: 12589832
DOI: 10.1016/s1386-6532(02)00263-9

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