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Article

Herpes simplex virus resistance to antiviral drugs.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Jan 2003

Morfin Florence, Thouvenot Danielle

Abstract excerpt

Herpes simplex virus (HSV) infections are efficiently treated with antiviral drugs such as acyclovir (ACV). However, resistance has been reported, mainly among immunocompromised patients (prevalence around 5%) and particularly allogeneic bone marrow transplant patients (prevalence reaching 30%). Resistance to ACV is associated with mutations on one of the two viral enzymes involved in the ACV mechanism of action:...

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Identifiers

PMID: 12589832
DOI: 10.1016/s1386-6532(02)00263-9

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