Article
Biochemical characterization of a virus isolate, recovered from a patient with herpes keratitis, that was clinically resistant to acyclovir.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 Dec 2001
Sarisky R T, Cano R, Nguyen T T, Wittrock R J, Duffy K E, Clark P, Bartus J O, Bacon T H, Caspers-Velu L, Hodinka R L, Leary J J
Abstract excerpt
In vitro susceptibility assays of herpes simplex virus (HSV) do not necessarily correlate with treatment outcome. An HSV type 1 (HSV-1) isolate, N4, recovered from a patient who presented with herpes keratitis with localized immunosuppression, was characterized for susceptibility. Although the 50% inhibitory concentration (IC(50)) for this isolate was less than the accepted breakpoint for defining resistance to...
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