Article
Systematic screening for mutations in the human serotonin-2A (5-HT2A) receptor gene: identification of two naturally occurring receptor variants and association analysis in schizophrenia.
Human genetics - 1 May 1996
Erdmann J, Shimron-Abarbanell D, Rietschel M, Albus M, Maier W, Körner J, Bondy B, Chen K, Shih J C, Knapp M, Propping P, Nöthen M M
Abstract excerpt
A statistically significant association between a silent mutation (102T/C) in the serotonin-2A (5-HT2A) receptor gene and schizophrenia has recently been reported in a sample of Japanese patients and healthy controls. This finding suggests that genetic predisposition to schizophrenia may be affected by a functional 5-HT2A receptor variant that is in linkage disequilibrium with 102T/C. In the present study, we...
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