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Article

Genetic Regulation of the Capacity to Make Immunoglobulin G to Pneumococcal Capsular Polysaccharides

1 Feb 1997

Abstract excerpt

BACKGROUND: Genetic regulation of immunoglobulin G(IgG) responses to pneumococcal capsular polysaccharides (PPS), has been demonstrated in mice but not in humans. Earlier studies from this laboratory showed that healthy adults have a varying capacity to generate IgG antibody to PPS; this study sought to determine whether this capacity is genetically controlled. METHODS: A 23-valent pneumococcal vaccine was...

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PMID: 9084576
DOI: 10.1177/108155899704500208

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