Article
Effect of Gm allotypes on IgG2 antibody responses and IgG2 concentrations in children and adults.
International immunology - 1 Jan 1990
Sarvas H, Rautonen N, Käyhty H, Kallio M, Mäkelä O
Abstract excerpt
Earlier studies have suggested that in adults the n-positive allele of the human IgG2 gene is more productive than the n-negative allele. This superiority was seen to be manifested in IgG2 antibody responses to polysaccharides, in the higher serum concentration of total IgG2 in the n/n than in -/- individuals, and in the higher concentration of n-positive than n-negative IgG2 in heterozygotes. The present study...
Topics
- Adult
- Age Factors
- Alleles
- Bacterial Capsules
- Bacterial Vaccines
- Child, Preschool
- Diphtheria Toxoid
- Haemophilus Vaccines
- Haemophilus influenzae
- Heterozygote
- Humans