Article
Increased frequency of HLA-DR4 allele in women with unexplained recurrent spontaneous abortions, detected by the method of PCR-SSP.
Journal of reproductive immunology - 1 Feb 1997
Sasaki T, Yamada H, Kato E H, Sudo S, Kishida T, Sasaki T, Nishigaki F, Fujimoto S
Abstract excerpt
We investigated whether HLA-DR genes are associated with the etiology of unexplained recurrent spontaneous abortion (URSA), by using the polymerase chain reaction-sequence-specific primers (PCR-SSP) method, which is more accurate than serological typing. In women (n = 27) who experienced three or more consecutive spontaneous abortions in the first trimester, the frequency of the DR4 allele was significantly...
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