Article
Maternal HLA class II alleles predispose to pregnancy losses in Danish women with recurrent spontaneous abortions and their female relatives.
American journal of reproductive immunology (New York, N.Y. : 1989) - 1 Mar 1996
Christiansen O B, Pedersen B, Mathiesen O, Husth M, Grunnet N
Abstract excerpt
PROBLEM: If damage to the trophoblast mediated through autoimmune mechanisms is responsible for recurrent spontaneous abortions (RSA), maternal class II HLA antigens might be expected to be involved. We wanted to evaluate the impact of these antigens on pregnancy outcome in RSA women and their relatives. METHOD: HLA-DR and -DQ typing using RFLP and PCR-SSP methods was carried out in 234 Danish women with...
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