Article
Implication of HLA-G 5' upstream regulatory region polymorphisms in idiopathic recurrent spontaneous abortions.
Reproductive biomedicine online - 1 Jan 2015
Agrawal Divya, Prakash Swayam, Misra Maneesh Kumar, Phadke Shubha R, Agrawal Suraksha
Abstract excerpt
The effect of HLA-G 5'-upstream regulatory region (URR) single nucleotide polymorphisms (SNP) in idiopathic recurrent spontaneous abortion (RSA) was evaluated. Parental genotype combination analysis and HLA-G expression at transcriptional level was evaluated for 5'URR SNP, which have shown increased risk for idiopathic RSA. If a fetus were aneuploid, attributing causation to a HLA-G 5'-URR SNP would be illogical;...
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