Article
Role of 14-bp insertion/deletion polymorphism in HLA-G among Indian women with recurrent spontaneous abortions.
Tissue antigens - 1 Feb 2011
Aruna M, Sirisha P V S, Andal Bhaskar S, Tarakeswari S, Thangaraj K, Reddy B M
Abstract excerpt
Human leukocyte antigen (HLA)-G is predominantly expressed on the extravillous cytotrophoblasts at the fetal-maternal interface. The 14-bp polymorphism in exon 8 is associated with HLA-G messenger ribonucleic acid (mRNA) stability and isoform alternative splicing patterns, thereby influencing the functionality of HLA-G in pregnancy. We analysed the 14-bp indel polymorphism in 143 recurrent spontaneous abortions...
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