Article
Molecular screening for somatic mutations in corticotropic adenomas of dogs with pituitary-dependent hyperadrenocorticism.
Journal of endocrinological investigation - 1 Jan 1997
van Wijk P A, Rijnberk A, Croughs R J, Meij B P, van Leeuwen I S, Sprang E P, Mol J A
Abstract excerpt
Pituitary tumorigenesis is now generally regarded as a multistep process of genomic damage leading to uncoupling of interdependent systems that control cell proliferation and differentiation. The alterations include mutations in genes encoding for proteins involved in signal transduction pathways...
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