Article
Is the common 677C-->T mutation in the methylenetetrahydrofolate reductase gene a risk factor for neural tube defects? A meta-analysis.
QJM : monthly journal of the Association of Physicians - 1 Feb 1997
van der Put N M, Eskes T K, Blom H J
Abstract excerpt
The common 677C-->T mutation (+) in the 5,10-methylenetetrahydrofolate reductase gene, resulting in decreased activity of the enzyme, has been associated with spina bifida neural tube defects (NTD). We combined all known Dutch control groups, a total of 1273 individuals, and found a prevalence of the 677C-->T mutation of 8.4%. When compared with the frequencies in 55 SB patients and to mothers with a child with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.