Article
Cysteine-rich FGF receptor regulates intracellular FGF-1 and FGF-2 levels.
Journal of cellular physiology - 1 Mar 1997
Zuber M E, Zhou Z, Burrus L W, Olwin B B
Abstract excerpt
The cysteine-rich FGF receptor (CFR) is a 150-kD membrane-associated glycoprotein that specifically binds FGFs. CFR protein is not detectable at the cell surface and immunocytochemistry with anti-CFR antibodies demonstrates that CFR is concentrated in the Golgi apparatus. These data suggest CFR does not function as a plasma membrane FGF receptor. CFR expressed in chinese hamster ovary cells reduces the...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Binding, Competitive
- Biological Transport
- CHO Cells
- Cricetinae
- Cysteine
- Fibroblast Growth Factor 1
- Fibroblast Growth Factor 2
- Fluorescent Antibody Technique, Indirect
- Golgi Apparatus
- Iodine Radioisotopes
- Molecular Sequence Data
- Mutation
- Protein Structure, Tertiary
- Receptors, Fibroblast Growth Factor
- Subcellular Fractions