Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cysteine-rich fibroblast growth factor receptor alters secretion and intracellular routing of fibroblast growth factor 3.

The Journal of biological chemistry - 26 May 2000

Köhl R, Antoine M, Olwin B B, Dickson C, Kiefer P

Abstract excerpt

Expression of the cysteine-rich fibroblast growth factor (FGF) receptor (CFR) in COS-1 cells strongly inhibits the secretion of co-expressed FGF3. By using a column retention assay and affinity chromatography, we demonstrate that at physiological salt concentrations FGF3 binds with strong affinity to CFR in vivo and in vitro. Furthermore, to show that FGF3 binds to CFR in vivo, truncation mutants of CFR with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chickens
Share to COS Cells
Share to Extracellular Matrix

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblast Growth Factors

Share to Fluorescent Antibody Technique

Share to Membrane Glycoproteins

Share to Proto-Oncogene Proteins

Share to Receptors, Fibroblast Growth Factor

Source

Identifiers

PMID: 10748074
DOI: 10.1074/jbc.M903271199

Genes

FGF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cysteine-rich fibroblast growth factor receptor alters secretion and intracellular routing of fibroblast growth factor 3.PMID 10748074Read ↗

Cysteine-rich FGF receptor regulates intracellular FGF-1 and FGF-2 levels.Semantic proximity Read ↗

Secreted cysteine-rich FGF receptor derives from posttranslational processing by furin-like prohormone convertases.Semantic proximity Read ↗

High molecular weight FGF2: the biology of a nuclear growth factor.Semantic proximity Read ↗

Different abilities of the four FGFRs to mediate FGF-1 translocation are linked to differences in the receptor C-terminal tail.Semantic proximity Read ↗

Intracellular retention, degradation, and signaling of glycosylation-deficient FGFR2 and craniosynostosis syndrome-associated FGFR2C278F.Semantic proximity Read ↗

Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform.Semantic proximity Read ↗

A hydrophobic region locating at the center of fibroblast growth factor-9 is crucial for its secretion.Semantic proximity Read ↗

Coexpression of G-CSF with an unglycosylated G-CSF receptor mutant results in secretion of a stable complex.Semantic proximity Read ↗

Folding of Fibroblast Growth Factor 1 Is Critical for Its Nonclassical Release.Semantic proximity Read ↗

ER reorganization is remarkably induced in COS-7 cells accumulating transmembrane protein receptors not competent for export from the endoplasmic reticulum.Semantic proximity Read ↗

Lysyl hydroxylase 3 is secreted from cells by two pathways.Semantic proximity Read ↗

Modulation of intracellular transport of acidic fibroblast growth factor by mutations in the cytoplasmic receptor domain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.