Article
The C-terminal RNLL sequence of the plasma retinol-binding protein is not responsible for its intracellular retention.
Biochemical and biophysical research communications - 16 Apr 1996
Natarajan V, Holven K B, Reppe S, Blomhoff R, Moskaug J O
Abstract excerpt
An in vitro model system using COS cells that transiently express human plasma retinol binding protein has been set up in which we are able to mimic the retinol dependent secretion of this protein observed in hepatocytes. In the absence of its ligand, plasma retinol binding protein is retained in the endoplasmic reticulum. It contains a C-terminal sequence, RNLL, that could function as a cryptic KDEL motif and...
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