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Article

Association of cytochrome P450 2E1 polymorphisms and head and neck squamous cell cancer.

Toxicology letters - 15 Jun 2004

Neuhaus Thomas, Ko Yon-Dschun, Lorenzen Katrin, Fronhoffs Stefan, Harth Volker, Bröde Peter, Vetter Hans, Bolt Hermann M, Pesch Beate, Brüning Thomas

Abstract excerpt

The development of head and neck squamous cell cancer (HNSCC) is known to be strongly associated with tobacco use. One of the main enzymes for bioactivation of tobacco-related substances is the cytochrome 450 (CYP)2E1, of which different genetic variants are described. Analyzing a correlation between certain neoplasia and alteration of the CYP2E1 gene, most studies focus on the polymorphisms -1053C>T and 7632T>A,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15177663
DOI: 10.1016/j.toxlet.2003.09.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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