Article

Analysis of spike protein variants evolved in a novel mouse model of persistent SARS-CoV-2 infection

2023-03-20

Abstract excerpt

SARS-CoV-2 mutation rates have increased over time, resulting in the emergence of several variants of concern. Persistent infection is assumed to be involved in the evolution of the variants; however, there is currently no animal model to recapitulate persistent infection. We established a novel model of persistent infection using xenografts of Calu-3 human lung cancer cells in immunocompromised mice. After infect...

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Literature Corpus work: 96bd670e-b926-5abd-9de9-8bcdde6e42eb
DOI: 10.1101/2023.03.19.533317

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