Article
A single genetic origin for the common prothrombotic G20210A polymorphism in the prothrombin gene.
Blood - 15 Aug 1998
Zivelin A, Rosenberg N, Faier S, Kornbrot N, Peretz H, Mannhalter C, Horellou M H, Seligsohn U
Abstract excerpt
The polymorphism G20210A in the 3' untranslated region of the prothrombin gene is associated with an increased level of factor II activity and confers a twofold to fivefold increase in the risk for venous thromboembolism. Among Caucasian populations, the prevalence of factor II G20210A heterozygo...
Topics
- Africa, Northern
- Alleles
- Ethnicity
- Europe
- Evolution, Molecular
- Gene Frequency
- Genotype
- Haplotypes
- Humans
- Jews
- Middle East
- Point Mutation
- Prevalence
- Prothrombin
- Risk
- Thrombophilia