Article
Mutation in the gene coding for coagulation factor V and the risk of myocardial infarction, stroke, and venous thrombosis in apparently healthy men.
The New England journal of medicine - 6 Apr 1995
Ridker P M, Hennekens C H, Lindpaintner K, Stampfer M J, Eisenberg P R, Miletich J P
Abstract excerpt
BACKGROUND: A specific point mutation in the gene coding for coagulation factor V is associated with resistance to degradation by activated protein C, a recently described abnormality of coagulation that may be associated with an increased risk of venous thrombosis. Whether this mutation also predisposes patients to arterial thrombosis is unknown, as is the value of screening for the mutation in order to define...
Topics
- Aged
- Base Sequence
- Cerebrovascular Disorders
- Confidence Intervals
- Factor V
- Follow-Up Studies
- Genetic Markers
- Genetic Predisposition to Disease
- Humans
- Male
- Molecular Sequence Data