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Article

Crosstalk between Nodal/activin and MAPK p38 signaling is essential for anterior-posterior axis specification.

Current biology : CB - 9 Aug 2011

Clements Melanie, Pernaute Barbara, Vella Francis, Rodriguez Tristan A

Abstract excerpt

Nodal/activin signaling plays a key role in anterior-posterior (A-P) axis formation by inducing the anterior visceral endoderm (AVE), the extraembryonic signaling center that initiates anterior patterning in the embryo. Here we provide direct evidence that the mitogen-activated protein kinase (MAPK) p38 regulates AVE specification through a crosstalk with the Nodal/activin signaling pathway. We show that p38...

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Identifiers

PMID: 21802298
DOI: 10.1016/j.cub.2011.06.048
PMCID: PMC3209556

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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