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Article

Structure-activity relationships for substituted bis(acridine-4-carboxamides): a new class of anticancer agents.

Journal of medicinal chemistry - 1 Jul 1999

Gamage S A, Spicer J A, Atwell G J, Finlay G J, Baguley B C, Denny W A

Abstract excerpt

A series of acridine-substituted bis(acridine-4-carboxamides) linked by a (CH2)3N(Me)(CH2)3 chain have been prepared by reaction of the isolated imidazolides of the substituted acridine-4-carboxylic acids with N,N-bis(3-aminopropyl)methylamine. These dimeric analogues of the mixed topoisomerase I/II inhibitor N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA), currently in clinical trial, show superior...

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Identifiers

PMID: 10395479
DOI: 10.1021/jm980687m

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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