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Article

Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum.

Antimicrobial agents and chemotherapy - 1 Nov 2007

Kelly Jane X, Smilkstein Martin J, Cooper Roland A, Lane Kristin D, Johnson Robert A, Janowsky Aaron, Dodean Rozalia A, Hinrichs David J, Winter Rolf, Riscoe Michael

Abstract excerpt

A series of novel 10-N-substituted acridones, bearing alkyl side chains with tertiary amine groups at the terminal position, were designed, synthesized, and evaluated for the ability to enhance the potency of quinoline drugs against multidrug-resistant (MDR) Plasmodium falciparum malaria parasite...

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Identifiers

PMID: 17846138
DOI: 10.1128/AAC.00669-07
PMCID: PMC2151415

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17846138-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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