Article
Comparative cytotoxicities of a series of ellipticine and olivacine derivatives on multidrug resistant cells of human and murine origins.
Anti-cancer drug design - 1 Nov 1990
Chevallier-Multon M C, Jacquemin-Sablon A, Besselièvre R, Husson H P, Le Pecq J B
Abstract excerpt
The MDR P-glycoprotein has been described as a major factor of multidrug resistance. This transmembrane glycoprotein acts like an energy dependent efflux pump which possesses a broad specificity. It seems to be acting as a pump requiring drug fixation prior to extrusion. With the aim of investigating which parameters influence the recognition of drugs by the MDR system, we have determined the toxicities of...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Antineoplastic Agents, Phytogenic
- Cell Survival
- Doxorubicin
- Drug Resistance
- Drug Screening Assays, Antitumor
- Ellipticines
- Gene Amplification
- Humans