Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Localization of structural elements of bee venom phospholipase A2 involved in N-type receptor binding and neurotoxicity.

The Journal of biological chemistry - 14 Mar 1997

Nicolas J P, Lin Y, Lambeau G, Ghomashchi F, Lazdunski M, Gelb M H

Abstract excerpt

We have shown previously that neurotoxic venom secretory phospholipases A2 (sPLA2s) have specific receptors in brain membranes called N-type receptors that are likely to play a role in the molecular events leading to neurotoxicity of these proteins. The sPLA2 found in honey bee venom is neurotoxic and binds to this receptor with high affinity. In this paper, we have used a number of mutants of bee venom sPLA2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Binding Sites

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Escherichia coli

Share to Molecular Sequence Data

Share to Mutation

Share to Phospholipases A

Share to Protein Conformation

Share to Receptors, Cell Surface

Source

Identifiers

PMID: 9054413
DOI: 10.1074/jbc.272.11.7173

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Localization of structural elements of bee venom phospholipase A2 involved in N-type receptor binding and neurotoxicity.PMID 9054413Read ↗

Mapping the structural determinants of presynaptic neurotoxicity of snake venom phospholipases A2.Semantic proximity Read ↗

Mutations on the N-terminal region abolish differentially the enzymatic activity, membrane-damaging activity and cytotoxicity of Taiwan cobra phospholipase A2.Semantic proximity Read ↗

Mutations on N-terminal region of Taiwan cobra phospholipase A(2) result in structurally distorted effects.Semantic proximity Read ↗

The C-terminal and beta-wing regions of ammodytoxin A, a neurotoxic phospholipase A2 from Vipera ammodytes ammodytes, are critical for binding to factor Xa and for anticoagulant effect.Semantic proximity Read ↗

Mapping structural determinants of biological activities in snake venom phospholipases A2 by sequence analysis and site directed mutagenesis.Semantic proximity Read ↗

N-Terminal domain of annexin 2 regulates Ca(2+)-dependent membrane aggregation by the core domain: a site directed mutagenesis study.Semantic proximity Read ↗

Mapping the phospholipid-binding surface and translocation determinants of the C2 domain from cytosolic phospholipase A2.Semantic proximity Read ↗

Production in Escherichia coli, folding, purification and characterization of notexin with wild type sequence and with N-terminal and catalytic site mutations.Semantic proximity Read ↗

Roles of catalytic domain residues in interfacial binding and activation of group IV cytosolic phospholipase A2.Semantic proximity Read ↗

Mapping the anthrax protective antigen binding site on the lethal and edema factors.Semantic proximity Read ↗

Purification and characterization of a mutant human platelet phospholipase A2 expressed in Escherichia coli. Cleavage of a fusion protein with cyanogen bromide.Semantic proximity Read ↗

Brown spider phospholipase-D containing a conservative mutation (D233E) in the catalytic site: identification and functional characterization.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.