Localization of structural elements of bee venom phospholipase A2 involved in N-type receptor binding and neurotoxicity.

doi:10.1074/jbc.272.11.7173

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Article

Localization of structural elements of bee venom phospholipase A2 involved in N-type receptor binding and neurotoxicity.

The Journal of biological chemistry - 14 Mar 1997

Nicolas J P, Lin Y, Lambeau G, Ghomashchi F, Lazdunski M, Gelb M H

Abstract excerpt

We have shown previously that neurotoxic venom secretory phospholipases A2 (sPLA2s) have specific receptors in brain membranes called N-type receptors that are likely to play a role in the molecular events leading to neurotoxicity of these proteins. The sPLA2 found in honey bee venom is neurotoxi...

Topics

Animals
Base Sequence
Bee Venoms
Binding Sites
Escherichia coli
Molecular Sequence Data
Mutation
Phospholipases A
Phospholipases A2
Protein Conformation
Receptors, Cell Surface

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