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Article

Brown spider phospholipase-D containing a conservative mutation (D233E) in the catalytic site: identification and functional characterization.

Journal of cellular biochemistry - 1 Nov 2013

Vuitika Larissa, Gremski Luiza Helena, Belisário-Ferrari Matheus Regis, Chaves-Moreira Daniele, Ferrer Valéria Pereira, Senff-Ribeiro Andrea, Chaim Olga Meiri, Veiga Silvio Sanches

Abstract excerpt

UNLABELLED: Brown spider (Loxosceles genus) bites have been reported worldwide. The venom contains a complex composition of several toxins, including phospholipases-D. Native or recombinant phospholipase-D toxins induce cutaneous and systemic loxoscelism, particularly necrotic lesions, inflammatory response, renal failure, and hematological disturbances. Herein, we describe the cloning, heterologous expression...

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PMID: 23733617
DOI: 10.1002/jcb.24594

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