Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of HIV-1 env gene sequences reveals evidence for a low effective number in the viral population.

Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 1997

Brown A J

Abstract excerpt

Selection is usually considered to be the dominant force controlling viral variation; the large population sizes suggest that deterministic population genetic models are appropriate. To investigate their validity for HIV, samples of env gene sequences were tested for departure from neutrality because of mutation-selection balance. None of the samples departed significantly when tested as nucleotide sequences. At...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Genetic Variation
Share to Genetics, Population

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Genetic

Share to Mutation

Share to Peptide Fragments

Share to RNA, Viral

Source

Open in PubMed Open full text

Identifiers

PMID: 9050870
DOI: 10.1073/pnas.94.5.1862
PMCID: PMC20008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Analysis of HIV-1 env gene sequences reveals evidence for a low effective number in the viral population.PMID 9050870Read ↗

Linkage disequilibrium test implies a large effective population number for HIV in vivo.Semantic proximity Read ↗

Evolution of intrahost HIV-1 genetic diversity during chronic infection.Semantic proximity Read ↗

Taking multiple infections of cells and recombination into account leads to small within-host effective-population-size estimates of HIV-1.Semantic proximity Read ↗

Selection dramatically reduces effective population size in HIV-1 infection.Semantic proximity Read ↗

Population dynamics of HIV-1 inferred from gene sequences.Semantic proximity Read ↗

Influence of random genetic drift on human immunodeficiency virus type 1 env evolution during chronic infection.Semantic proximity Read ↗

Evidence for negative selective pressure in HIV-2 evolution in vivo.Semantic proximity Read ↗

Stochastic processes strongly influence HIV-1 evolution during suboptimal protease-inhibitor therapy.Semantic proximity Read ↗

Evolution of the human immunodeficiency virus envelope gene is dominated by purifying selection.Semantic proximity Read ↗

Estimation of effective population size of HIV-1 within a host: a pseudomaximum-likelihood approach.Semantic proximity Read ↗

Sequence analysis of the V3 loop regions of the env genes of Ugandan human immunodeficiency proviruses.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.