Article
Stochastic processes strongly influence HIV-1 evolution during suboptimal protease-inhibitor therapy.
Proceedings of the National Academy of Sciences of the United States of America - 24 Nov 1998
Nijhuis M, Boucher C A, Schipper P, Leitner T, Schuurman R, Albert J
Abstract excerpt
It has long been assumed that HIV-1 evolution is best described by deterministic evolutionary models because of the large population size. Recently, however, it was suggested that the effective population size (Ne) may be rather small, thereby allowing chance to influence evolution, a situation best described by a stochastic evolutionary model. To gain experimental evidence supporting one of the evolutionary...
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