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Article

A mixed-charge pair in human interleukin 4 dominates high-affinity interaction with the receptor alpha chain.

Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 1997

Wang Y, Shen B J, Sebald W

Abstract excerpt

Human interleukin 4 (IL-4) binds to its cellular receptor with a Kd in the subnanomolar range, similar to many other 4-helix-bundle proteins interacting with members of the hematopoietin (cytokine) receptor superfamily. In the IL-4 system this interaction is predominantly determined by the extrac...

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Identifiers

PMID: 9050834
DOI: 10.1073/pnas.94.5.1657
PMCID: PMC19972

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9050834-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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