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Article

The high-affinity interaction of human IL-4 and the receptor alpha chain is constituted by two independent binding clusters.

Journal of molecular biology - 18 Jan 2002

Zhang Jin-Li, Simeonowa Irina, Wang Yonghong, Sebald Walter

Abstract excerpt

IL4-BP, the extracellular binding domain of the IL-4 receptor alpha chain, contains a high-affinity binding epitope for IL-4 (K(D) 150 pM). Previous results on the crystal structure of the IL-4/IL4-BP complex and on the functional epitope of IL-4 suggested that this contact comprises a mosaic of two binding clusters. The present mutational analysis of IL4-BP supports this view and demonstrates that the...

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Identifiers

PMID: 11786020
DOI: 10.1006/jmbi.2001.5243

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