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Article

Structure of interleukin 4 mutant E9A suggests polar steering in receptor-complex formation.

Acta crystallographica. Section D, Biological crystallography - 1 Sept 2001

Hülsmeyer M, Scheufler C, Dreyer M K

Abstract excerpt

Interleukin 4 (IL-4) is a pleiotropic cytokine which induces T-cell differentiation and class switching of B cells. It therefore plays a central role in the development of allergies and asthma. An IL-4 variant in which Glu9 was mutated to alanine shows an 800-fold drop in binding affinity towards...

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Identifiers

PMID: 11526337
DOI: 10.1107/s0907444901009799

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11526337-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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