Article
Structural similarity of two T cell signaling regulators suggests a conserved and interactive mechanism of immunosuppression.
Molecular immunology - 1 Sept 1998
Vieira A
Abstract excerpt
A primary structural element is identified which is present in the Nef protein of immunodeficiency viruses and in the cytoplasmic domain of a regulatory T cell protein, CTLA-4. In both proteins, conserved residues that lie within this element have been shown to be important for the regulation of...
Topics
- Abatacept
- Amino Acid Sequence
- Animals
- Antigens, CD
- Antigens, Differentiation
- Binding Sites
- CTLA-4 Antigen
- Conserved Sequence
- Gene Products, nef
- HIV-1
- Humans
- Immune Tolerance
- Immunoconjugates
- Molecular Sequence Data
- Mutation
- Sequence Homology, Amino Acid
- Signal Transduction
- Simian Immunodeficiency Virus