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Article

Structural similarity of two T cell signaling regulators suggests a conserved and interactive mechanism of immunosuppression.

Molecular immunology - 1 Sept 1998

Vieira A

Abstract excerpt

A primary structural element is identified which is present in the Nef protein of immunodeficiency viruses and in the cytoplasmic domain of a regulatory T cell protein, CTLA-4. In both proteins, conserved residues that lie within this element have been shown to be important for the regulation of cellular signaling and endocytic trafficking. The structural similarity identified suggests conserved and, possibly,...

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Identifiers

PMID: 9839556
DOI: 10.1016/s0161-5890(98)00062-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Structural similarity of two T cell signaling regulators suggests a conserved and interactive mechanism of immunosuppression.PMID 9839556Read ↗

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