Article

Catch bonds in sickle cell disease: shear-enhanced adhesion of red blood cells to laminin

2022-11-13

Abstract excerpt

<h4>ABSTRACT</h4> Could the phenomenon of catch bonding—force-strengthened cellular adhesion—play a role in sickle cell disease, where abnormal red blood cell (RBC) adhesion obstructs blood flow? Here we investigate the dynamics of sickle RBCs adhering to a surface functionalized with the protein laminin (a component of the extracellular matrix around blood vessels) under physiologically relevant micro-scale flow...

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Literature Corpus work: 227c4a5a-06b7-5cdb-a61b-6ebd9ef612c3
DOI: 10.1101/2022.11.12.515898

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