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Article

Use of Probe Drugs as Predictors of Drug Metabolism in Humans

1 Jan 1997

Abstract excerpt

The pharmacokinetics of many drugs often vary considerably among individuals, largely because of variations in the expression of different cytochrome P-450 (CYP) enzymes in the liver and other tissues. Relatively selective substrate probes in vivo have been discovered for several major CYP isoforms involved in oxidative drug metabolism. Regarding isoforms that show genetic polymorphism (CYP2C19 and CYP2D6),...

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PMID: 9048284
DOI: 10.1177/009127009703700121

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