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Article

Identification of a dominant-negative mutation in the yeast CDC25 guanine nucleotide exchange factor for Ras.

Oncogene - 20 Feb 1997

Park W, Mosteller R D, Broek D

Abstract excerpt

In previous studies we changed five conserved amino acid residues in the catalytic domain of the yeast Ras-specific guanine nucleotide exchange factor CDC25GEF (Park et al., 1994). One of the substitutions (R1489E) resulted in a molecule which could bind Ras but was catalytically inactive. These observations suggested that CDC25R1489E might be a dominant-negative mutant. Here we report further experiments which...

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Identifiers

PMID: 9047390
DOI: 10.1038/sj.onc.1200893

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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