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Article

Interaction between the Saccharomyces cerevisiae CDC25 gene product and mammalian ras.

The Journal of biological chemistry - 15 Nov 1992

Segal M, Marbach I, Engelberg D, Simchen G, Levitzki A

Abstract excerpt

In order to characterize the interaction between the Saccharomyces cerevisiae Cdc25 protein and Harvey-ras (p21H-ras), we have constructed a yeast strain disrupted at the RAS1 and RAS2 loci, expressing both p21H-ras and the catalytic domain of the bovine GTPase activating protein (GAP) and containing the cdc25-2 mutation. Such a strain exhibits a temperature-sensitive phenotype. The shift to the nonpermissive...

Topics

Adenylyl Cyclases
Animals
Cell Cycle Proteins
Cell Membrane
Cloning, Molecular
Fungal Proteins
Genes, Fungal
Genes, ras
Genotype
Kinetics
Mammals
Plasmids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins p21(ras)

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

ras Proteins

ras-GRF1

Source

Identifiers

PMID: 1429624

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1429624-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Interaction between the Saccharomyces cerevisiae CDC25 gene product and mammalian ras.PMID 1429624Read ↗

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Dimerization of Cdc25p, the guanine-nucleotide exchange factor for Ras from Saccharomyces cerevisiae, and its interaction with Sdc25p.Semantic proximity Read ↗

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