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Article

HOXB5 binds to multi-species conserved sequence (MCS+9.7) of RET gene and regulates RET expression.

The international journal of biochemistry & cell biology - 1 Jun 2014

Zhu Joe Jiang, Kam Mandy KaMan, Garcia-Barceló Maria-Mercè, Tam Paul Kwong Hang, Lui Vincent Chi Hang

Abstract excerpt

RET gene is crucial for the development of enteric nervous system, and dys-regulation of RET expression causes Hirschsprung disease. HOXB5 regulates RET transcription, and perturbations in transcriptional regulation by HOXB5 caused reduced RET expression and defective enteric nervous system development in mice. The mechanisms by which HOXB5 regulate RET transcription are unclear. Thus, unraveling the regulatory...

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Identifiers

PMID: 24794774
DOI: 10.1016/j.biocel.2014.04.013

Genes

RET
HOXB5

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Related research

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HOXB5 binds to multi-species conserved sequence (MCS+9.7) of RET gene and regulates RET expression.PMID 24794774Read ↗

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A New Transgenic Tool to Study the Ret Signaling Pathway in the Enteric Nervous SystemSemantic proximity Read ↗

Correlation between genetic variations in Hox clusters and Hirschsprung's disease.Semantic proximity Read ↗

Variants in RET associated with Hirschsprung's disease affect binding of transcription factors and gene expression.Semantic proximity Read ↗

Conservation of RET Regulatory Function from Human to Zebrafish Without Sequence SimilaritySemantic proximity Read ↗

Sox10 and Pax3 physically interact to mediate activation of a conserved c-RET enhancer.Semantic proximity Read ↗

Long-range regulation by shared retinoic acid response elements modulates dynamic expression of posterior Hoxb genes in CNS development.Semantic proximity Read ↗

<i>HOXB5</i> expression is spatially and temporarily regulated in human embryonic gut during neural crest cell colonization and differentiation of enteric neuroblastsSemantic proximity Read ↗

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