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Article

Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction.

Oncogene - 12 Apr 2001

Kurokawa K, Iwashita T, Murakami H, Hayashi H, Kawai K, Takahashi M

Abstract excerpt

SNT/FRS2 is a lipid anchored docking protein that contains an amino-terminal myristylation signal, followed by a phosphotyrosine-binding (PTB) domain and a carboxy-terminal region with multiple tyrosine residues. Here we show that the SNT/FRS2 PTB domain binds to RET receptor tyrosine kinase activated by glial cell line-derived neurotrophic factor (GDNF) or multiple endocrine neoplasia (MEN) 2 mutations. Analyses...

Read the complete abstract on PubMed

Topics

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Share to Glial Cell Line-Derived Neurotrophic Factor
Share to Glial Cell Line-Derived Neurotrophic Factor Receptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GRB2 Adaptor Protein

Share to Multiple Endocrine Neoplasia Type 2a

Share to Nerve Growth Factors

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 11

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 6

Share to Proto-Oncogene Proteins c-ret

Source

Identifiers

PMID: 11360177
DOI: 10.1038/sj.onc.1204290

Genes

FRS2
RET
GRB2
GAB1
GDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction.PMID 11360177Read ↗

Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade.Semantic proximity Read ↗

Identification of Shc docking site on Ret tyrosine kinase.Semantic proximity Read ↗

Differential membrane compartmentalization of Ret by PTB-adaptor engagement.Semantic proximity Read ↗

SNT-2 interacts with ERK2 and negatively regulates ERK2 signaling in response to EGF stimulation.Semantic proximity Read ↗

Characterization of Ret-Shc-Grb2 complex induced by GDNF, MEN 2A, and MEN 2B mutations.Semantic proximity Read ↗

The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors.Semantic proximity Read ↗

Fibroblast growth factor receptor 1 (FGFR1) tyrosine phosphorylation regulates binding of FGFR substrate 2alpha (FRS2alpha) but not FRS2 to the receptor.Semantic proximity Read ↗

Protein-tyrosine phosphatase SHP2 contributes to GDNF neurotrophic activity through direct binding to phospho-Tyr687 in the RET receptor tyrosine kinase.Semantic proximity Read ↗

Tyrosine phosphorylation sites on FRS2alpha responsible for Shp2 recruitment are critical for induction of lens and retina.Semantic proximity Read ↗

Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase.Semantic proximity Read ↗

A mutation at tyrosine 1062 in MEN2A-Ret and MEN2B-Ret impairs their transforming activity and association with shc adaptor proteins.Semantic proximity Read ↗

Subcellular receptor redistribution and enhanced microspike formation by a Ret receptor preferentially recruiting Dok.Semantic proximity Read ↗

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