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Article

In vitro effects of a C4'-oxidized abasic site on DNA polymerases.

Biochemistry - 9 Mar 2004

Greenberg Marc M, Weledji Yvonne N, Kroeger Kelly M, Kim Jaeseung, Goodman Myron F

Abstract excerpt

Oxidative damage to DNA produces abasic sites resulting from the formal hydrolysis of the nucleotides' glycosidic bonds, along with a variety of oxidized abasic sites. The C4'-oxidized abasic site (C4-AP) is produced by several DNA-damaging agents. This lesion accounts for approximately 40% of the DNA damage produced by bleomycin. The effect of a C4'-oxidized abasic site incorporated at a defined site in a...

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Identifiers

PMID: 14992603
DOI: 10.1021/bi036028f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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