Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Detecting disease-predisposing variants: the haplotype method.

American journal of human genetics - 1 Mar 1997

Valdes A M, Thomson G

Abstract excerpt

For many HLA-associated diseases, multiple alleles-- and, in some cases, multiple loci--have been suggested as the causative agents. The haplotype method for identifying disease-predisposing amino acids in a genetic region is a stratification analysis. We show that, for each haplotype combination...

Topics

Amino Acids
Arthritis, Rheumatoid
Autoimmune Diseases
Computer Simulation
Diabetes Mellitus, Type 1
Genetic Predisposition to Disease
HLA Antigens
HLA-DQ Antigens
HLA-DQ alpha-Chains
HLA-DQ beta-Chains
HLA-DR Antigens
HLA-DRB1 Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Haplotypes

Humans

Models, Genetic

Models, Statistical

Source

Open in PubMed Open full text

Identifiers

PMID: 9042931
PMCID: PMC1712525

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9042931-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Detecting disease-predisposing variants: the haplotype method.PMID 9042931Read ↗

A permutation procedure for the haplotype method for identification of disease-predisposing variants.Semantic proximity Read ↗

HLA class II DR-DQ amino acids and insulin-dependent diabetes mellitus: application of the haplotype method.Semantic proximity Read ↗

Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes: a meta-analysis.Semantic proximity Read ↗

Progression to type 1 diabetes in the DPT-1 and TN07 clinical trials is critically associated with specific residues in HLA-DQA1-B1 heterodimers.Semantic proximity Read ↗

A systematic search for SNPs/haplotypes associated with disease phenotypes using a haplotype-based stepwise procedure.Semantic proximity Read ↗

Haplotype-based search for SNPs associated with differential type 1 diabetes risk among chromosomes carrying a specific HLA DRB1-DQA1-DQB1 haplotype.Semantic proximity Read ↗

Motifs of Three HLA-DQ Amino Acid Residues (α44, β57, β135) Capture Full Association With the Risk of Type 1 Diabetes in DQ2 and DQ8 Children.Semantic proximity Read ↗

Combined effect of glutamine at position 70 of HLA-DRB1 and alanine at position 57 of HLA-DQB1 in type 1 diabetes: An epitope analysis.Semantic proximity Read ↗

Improved risk assessment for insulin-dependent diabetes mellitus by analysis of amino acids in HLA-DQ and DRB1 loci.Semantic proximity Read ↗

Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk.Semantic proximity Read ↗

Next-Generation HLA Sequence Analysis Uncovers Seven HLA-DQ Amino Acid Residues and Six Motifs Resistant to Childhood Type 1 Diabetes.Semantic proximity Read ↗

Worldwide differences in the incidence of type I diabetes are associated with amino acid variation at position 57 of the HLA-DQ beta chain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.