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Article

Detecting disease-predisposing variants: the haplotype method.

American journal of human genetics - 1 Mar 1997

Valdes A M, Thomson G

Abstract excerpt

For many HLA-associated diseases, multiple alleles-- and, in some cases, multiple loci--have been suggested as the causative agents. The haplotype method for identifying disease-predisposing amino acids in a genetic region is a stratification analysis. We show that, for each haplotype combination containing all the amino acid sites involved in the disease process, the relative frequencies of amino acid variants...

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Share to Amino Acids
Share to Diabetes Mellitus, Type 1
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to HLA Antigens

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Source

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Identifiers

PMID: 9042931
PMCID: PMC1712525

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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