Article
A systematic search for SNPs/haplotypes associated with disease phenotypes using a haplotype-based stepwise procedure.
BMC genetics - 22 Dec 2008
Yang Yin, Li Shuying Sue, Chien Jason W, Andriesen Jessica, Zhao Lue Ping
Abstract excerpt
BACKGROUND: Genotyping technologies enable us to genotype multiple Single Nucleotide Polymorphisms (SNPs) within selected genes/regions, providing data for haplotype association analysis. While haplotype-based association analysis is powerful for detecting untyped causal alleles in linkage-disequilibrium (LD) with neighboring SNPs/haplotypes, the inclusion of extraneous SNPs could reduce its power by increasing...
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