Article
A systematic search for SNPs/haplotypes associated with disease phenotypes using a haplotype-based stepwise procedure.
BMC genetics - 22 Dec 2008
Yang Yin, Li Shuying Sue, Chien Jason W, Andriesen Jessica, Zhao Lue Ping
Abstract excerpt
BACKGROUND: Genotyping technologies enable us to genotype multiple Single Nucleotide Polymorphisms (SNPs) within selected genes/regions, providing data for haplotype association analysis. While haplotype-based association analysis is powerful for detecting untyped causal alleles in linkage-disequilibrium (LD) with neighboring SNPs/haplotypes, the inclusion of extraneous SNPs could reduce its power by increasing...
Topics
- Algorithms
- Alleles
- Case-Control Studies
- Cohort Studies
- Computer Simulation
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Haplotypes
- Humans
- Linkage Disequilibrium