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Article

Mutation detection by electrocatalysis at DNA-modified electrodes.

Nature biotechnology - 1 Oct 2000

Boon E M, Ceres D M, Drummond T G, Hill M G, Barton J K

Abstract excerpt

Detection of mutations and damaged DNA bases is important for the early diagnosis of genetic disease. Here we describe an electrocatalytic method for the detection of single-base mismatches as well as DNA base lesions in fully hybridized duplexes, based on charge transport through DNA films. Gold electrodes modified with preassembled DNA duplexes are used to monitor the electrocatalytic signal of methylene blue,...

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PMID: 11017050
DOI: 10.1038/80301

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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