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Article

RET gene is a major risk factor for Hirschsprung's disease: a meta-analysis.

Pediatric surgery international - 1 Aug 2015

Tomuschat C, Puri P

Abstract excerpt

PURPOSE: During the past two decades several genes have been identified that control morphogenesis and differentiation of the enteric neuron system (ENS). These genes, when mutated or deleted, interfere with ENS development. RET gene is the major gene causing Hirschsprung's disease (HD). Mutations in RET gene are responsible for 50% of familial HD cases and 15-20% of sporadic cases. The aim of this meta-analysis...

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Source

Identifiers

PMID: 26164711
DOI: 10.1007/s00383-015-3731-y

Genes

RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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