Article
Determinants of susceptibility to challenge and the antibody response of adult volunteers given experimental respiratory syncytial virus vaccines.
Vaccine - 1 Jun 1990
Watt P J, Robinson B S, Pringle C R, Tyrrell D A
Abstract excerpt
The virulence and immunogenicity of a wild-type respiratory syncytial (RS) virus together with four temperature sensitive (ts) mutants derived from this isolate were tested by intranasal inoculation into adult volunteers. Resistance to challenge correlated with neutralizing antibody titres in nasal secretions and to a lesser extent in serum. All ts mutants were reduced in virulence. Mutant ts1B caused mild or...
Topics
- Adult
- Antibodies, Viral
- Humans
- Mutation
- Neutralization Tests
- Respiratory Syncytial Viruses
- Respiratory Tract Infections
- Respirovirus Infections
- Temperature
- Viral Vaccines