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Article

Novel Insertion Mutation in KCNJ5 Channel Produces Constitutive Aldosterone Release From H295R Cells.

Molecular endocrinology (Baltimore, Md.) - 1 Oct 2015

Hardege Iris, Xu Shengxin, Gordon Richard D, Thompson Andrew J, Figg Nichola, Stowasser Michael, Murrell-Lagnado Ruth, O'Shaughnessy Kevin M

Abstract excerpt

Primary aldosteronism accounts for 5%-10% of hypertension and in a third of cases is caused by autonomous aldosterone production by adenomas (APA). Somatic mutations in the potassium channel encoded by KCNJ5 have been detected in surgically removed APAs. To better understand the role of these mutations, we resequenced the KCNJ5 channel in a large Australian primary aldosteronism cohort. KCNJ5 mutations were...

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Identifiers

PMID: 26340408
DOI: 10.1210/me.2015-1195
PMCID: PMC5414677

Genes

KCNJ5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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