Article
Thyroid hyperfunctioning adenomas with and without Gsp/TSH receptor mutations show similar clinical features.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association - 1 Jan 1998
Arturi F, Capula C, Chiefari E, Filetti S, Russo D
Abstract excerpt
Activating mutations of Gs alpha protein (gsp) and TSH receptor (TSH-R) identified in autonomously hyperfunctioning thyroid adenomas have been proposed as the primary event responsible for this disease. Since mutations have not been detected in 100% (ranging from less than 10% to 90%) of the pati...
Topics
- Adenoma
- Adult
- Female
- GTP-Binding Protein alpha Subunits, Gs
- Humans
- Male
- Middle Aged
- Mutation
- Receptors, Thyrotropin
- Thyroid Gland
- Thyroid Neoplasms
- Thyroidectomy
- Thyrotropin
- Thyroxine
- Triiodothyronine